Coronavirus replication–transcription complex: Vital and selective NMPylation of a conserved site in nsp9 by the NiRAN-RdRp subunit
نویسندگان
چکیده
Significance We report an intersubunit interaction within the coronavirus replication–transcription complex that is critical for replication and evolutionarily conserved. provide evidence nsp12-associated NiRAN domain has nucleoside monophosphate (NMP) transferase activity in trans identified nsp9, RNA-binding protein, as its target. catalyzes covalent attachment of NMP moiety to conserved nsp9 amino terminus a reaction dependent on Mn 2+ ions adjacent Asn residue. NMPylation were found be essential replication. The data lead us connect this nidovirus enzymatic marker with previous observations functionally coherent hypothesis initiation RNA synthesis class viruses.
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences of the United States of America
سال: 2021
ISSN: ['1091-6490', '0027-8424']
DOI: https://doi.org/10.1073/pnas.2022310118